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Ozone Safety

In spite of the so-called ozone “toxicity”, the incidence of adverse reactions is only 0.000007%, one of the lowest in medicine!  Even a Panadol is more harmful and has a lot more side effects.

When used properly, ozone therapy is considered a wholesome treatment with proven effects that are consistent and safe. Quality of life has been evaluated in a small sample of ozone therapy patients, and in accordance with the International Quality of Life Assessment, these patients reported an excellent quality of life following ozone therapy. Because of this feeling of wellness, patients also demonstrate excellent compliance rates.

“Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Medical O3 is used to disinfect and treat disease. Mechanism of actions is by inactivation of bacteria, viruses, fungi, yeast, and protozoa, stimulation of oxygen metabolism, activation of the immune system.”

— Elvis, A.M.
Ozone Therapy: A Clinical Review

Inhaling of Ozone is toxic, how can it be safe then to use internally?

Ozone protocol gut.005

Let’s clarify one important point: Ozone is toxic for inhalation.

This statement is true.

Our alveolar surface in the lungs is protected by a small amount of antioxidant content, which is insufficient in extinguishing the strong oxidant activity of ozone. In other words, your lungs simply don’t have enough antioxidants to deal with the potent power of this oxidative therapy.
That’s why breathing ozone in larger concentrations is harmful to the human being.

Nevertheless, the exact opposite is true for our blood and internal components as both our plasma and blood cells have a remarkable quantity of cooperating antioxidants. When administered ozone reacts within seconds with the organic components such as cells, blood, viruses, bacteria etc. and generates a number of chemical messengers responsible for activating crucial biological functions.

The free oxygen atom has the ability to combine and effect other substances which is the basis for ozone’s reactivity. 


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The eyes and lungs are very sensitive to ozone as they have minimal antioxidant and neutralizing capabilities and therefore ozone gas in greater concentrations should never contact eyes and lungs.

Ozone is contraindicated in patients with a significant deficit of Glucose-6-phosphate dehydrogenase deficiency (G-6PD- which is an inherited condition – causing red blood cells to break down in response to certain medication, infections or other stresses). This enzyme provides crucial reducing equivalents able to eliminate excessive oxidation and intensive haemolysis.

Ozone is contraindicated in pregnancy, merely as a precaution. In most European countries pregnant mothers are treated with ozone to provide extra oxygen and immunity to the baby. Also they do treat fresh born babies with ozone to help build a proper gut flora and to combat diseases like allergies, celiac and more which may have transferred from the mother.

Patients being treated with ACE inhibitors should be cautious with ozone and consult a practitioner.

Abnormal situations with hyperthyroidism, thrombocytopenia and serious cardio-vascular instability should also consult a practitioner before commencing with ozone therapy.

how does ozone effect disease

Summary of Contra-Indications

  1. All cases with Blood Coagulation Failure
  2. Bleeding Organs
  3. Thrombocytopenia
  4. Uncontrolled hyperthyroidism
  5. Acute alcohol intoxication
  6. Pregnancy
  7. Ozone Sensitivity / Allergy (very rare)
  8. Hemorrhagic or Apoplectic Stroke
  9. G6PD (extremely rare)

Side - Effects of Ozone

Allergic skin reactions are possible, although they are very uncommon. Rarely, patients experience an allergic skin reaction to a local topical application of ozone, which presents as a minor rash.
The two possible reasons for this rash could be a Herxheimer reaction (microbial die off) or an individual with a very low antioxidant status, unable to combat the ozone oxidation until these levels are restored.

Patient’s with serious chronic diseases such as Lyme disease should start slowly so that the body is not overwhelmed with the sudden change of higher oxygen availability, die off of pathogens and increase detoxification capacity. Ozone Therapy is still very well tolerated. Some patients may complain about weakness, slight dizziness, or sleepiness shortly during and after the the administration of ozone therapy.

A study of nearly 400,000 patients documented the frequency of side effects as occurring 1:1000-1:2000, making it statistically one of the safest drugs available.

“It depresses me to think that ozone, the cheapest drug on earth, is today either badly or minimally used because orthodox medicine refuses to evaluate it and Health Authorities are antagonistic or negligent. Both are responsible for leaving millions of people suffering and dying. I must not get discouraged and continue to work and hope that ozone therapy will eventually benefit many people.”

– Dr. Vellio Bocci –

ozone vitaminC.013

How to increase low Antioxidant levels

If your antioxidant levels are low than it is advisable to increase them. This can be achieved via antioxidant rich food or supplementation.

Antioxidant foods:
Berries (blueberries, goji berries, blackberries, raspberries, cranberries, elderberries), artichokes, dark chocolate, kidney beans, pecan nut, cilantro, broccoli, kale and spinach are examples of foods high in antioxidant levels.

Antioxidant supplements:
Glutathione, Quercetin, Vitamin C, Vitamin E, Astaxanthin, Resveratrol, Curcumin, Green tea extract, R-Lipoic Acid.

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16 Responses

  1. Marlene Welch says:

    I was wondering about ozone and COPD, will it work to decrease progression or help heal the problem

    1. Hello Marlene, as far as I know is COPD caused by an infection in the mucus membranes. The reason can be nay fold. You have absorbed too many toxins which prevent normal repair and function. You have co-infection which make things worse for your immune system. You have been infected by mold which blocks many detox and healing functions. You may even have food sensitivities which show as COPD and so on. There are hundreds of combinations that can lead to your condition. I would recommend a cause finding protocol to get to the root of your problems. You can book such a consultation here.

  2. I have a low g6pd, but have been able to use ozone therapy and high dose vitamin C therapy. Is there anything I should know about home use of ozone? I would like to buy the equipment for my sister and I to use at home. She has been diagnosed with diabetes and I have been diagnosed with Breast Cancer.

    Thanks so much,

    1. Hello Deborah, Almost every doctor said that rectal application of ozone is the most gentle form which neither triggers an allergy or any other contra indiction. Even patients with hyperthyroid usually tolerate ozone insufflations really well. Just start out slow with low volume and low concentrations and observe. For anyone having diabetes ozone rectal insufflations is mandatory. These people have contact elevated glucose levels which always leads to bacteria overgrowth and restricted blood vessels. It’s as I said mandatory.

  3. I went to my doctor 4 years ago with fatigue. She tested me for a variety of things and at the end of my appointment said she was going to test me for Epstein-Barr. She tested me for 3 antibodies. When I got my results, two of the three tests showed an elevation that was maybe twice the normal value, but the third one said my value was >600!! This is something like 40-50 times the highest normal value. I looked at her and asked what we can do about that and she shrugged her shoulders.
    4 years later I am still tired, try to workout hard but feel out of breath, tired, and have low motivation.

    I heard about UV light therapy as well as Ozone therapy and have watched videos by Robert Rowen and others. What form of ozone would be the most effective in treating my Epstein-Barr problem and about how many treatments would it take?



    1. Hello Dave
      yes I agree with you. Thats a long time to feel tired and exhausted. Let’s do something proactive. Ozone is proven to work against EBV. it’s not a fast therapy but still immensely effective over time. I have several patients who came from 400 down to 40 in a matter of 4 to 6 weeks. thats definitely faster than 4 years.

      If you can afford Hyperbaric multi pass Ozone therapy with any of the doctors you would have fastest results. If you do 3 times per week a MAHT you will also have fast results. If however you do not have a doctor nearby or it’s too expensive I would do rectal ozone insufflations 7 days a week for 4 to 8 weeks. It’s far cheaper and may be a bit slower but needle free. Plus you can do it in the morning when you are anyway in the bathroom. I have everything set up in my toilet and can do a treatment directly after a bowel movement. Its super easy and very quick.

  4. Carol Harrington says:

    I am wondering if it is contraindicated to use ozone in either rectal insuflation form or IV form when a person has hip implants where, even though there is not metal rubbing against metal as in the older style, there still are parts made with metals such as titanium, cobalt , etc.

    1. No contra indications at all.

  5. Hello Marcus!
    I am currently taking Ozone capsules internally as well as suppositories. Are the side-effects and contre-indications for those the same as Ozone therapy ?
    I am taking 4 to 8 capsules of oil per day (peroxyde index 500 per capsule) and the suppositoires (PI 92 per suppository) that I woud like to take up to 4 per day as well. Are there any risks/side effects additional than the one mentionned in this article ? Could i consume safely up to 8 capsules + 4 suppositories a day ? Even more if needed ? How could I know that I am not overdosing ? Thanks you so much for your help ! Have a lovely day !

    1. You let us know. Once you have worked out what works for you then please share. I have never pulled through the ozone capsules as they cause very unpleasant burbs which made me stop on day 2. And I never used suppositories either. It would be interesting to hear from your experience.

  6. Why is Ozone contraindicated in Hyperthyroid? As in what is the MOA at play and is there studies or other data you could link?
    It seems like western medicine really doesn’t understand hyperthyroid at all.
    One of your comments says it’s usually tolerated at low doses, I’m curious as to why it made the list though.
    Thanks for your time.

    1. Hello Tad, In my video I stated that with hyperthyroid DIV and Autohemotherapy are contraindicated but most patients have no problems with RI. Just be observant and see if your condition improves of worsens.

  7. Callum Dempsey says:

    Hi Marc, do you know where I can find any information of why Thrombocytopenia is a contraindication, my Mum has aplastic anaemia. Currently loving my machine for when I have a cold ect, but thought it could potentially help in her situation but maybe not. Was looking at it from immune modulating aspect as its an autoimmune disease.

    1. Hello Callum, Thrombocytopenia Is a condition where the body produces a low platelet count, which can lead to blood clotting problems such as bleeding.
      Ozone therapy is blood thinning therapy and therefore could aggravate the problem.

  8. hi Marcus! Have you seen Ozone effective against fungal balls in the sinuses? And ozone is effective for both bacterial and fungal sinus infections?

    1. Yes definitely. Just start slow and watch out that you train the breathing when doing ozone insufflations via sinus. You do not want to inhale ozone. Very unpleasant.

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contact us

Contact us with your preferred method. Calls are redirected to Qld Australia.  
If we are not answering leave a message so we can call you back.


Sunshine Coast Noosaville Qld 4566 Australia


Australia 1 800 719 673
USA & Canada 1 800 810 4796

Calls are redirected to Australia. Please leave a message so we can call you back.

WHATSAPP    +61 447 609022

ABN:   32 621 367 557
ACN:   621 367 557