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Ozone For Cancer Patients

Colon, Rectal, Prostate, Breast, Lung, Pancreas, Liver, and many more.
Ozone is not a treatment against cancer but for the patient!

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Second, the mild oxidative stress produced by ozone therapy stimulates the increase of cellular antioxidant enzymes (Nrf2 activator) capable of inhibiting chronic oxidative stress. In cancer, a persistent oxidative stress has been noted as a factor favoring the progression of invasion and metastasis and therefore important to counteract. The fact that cancer cells live better in a hypoxic environment may imply that they don’t have an antioxidant system to get rid of ROS. Therefore, ozone could exert important cytotoxic effects on neoplastic cells if they have a poor defense system. Furthermore, ozone accelerates the citric acid cycle and stimulates mitochondrial activity usually impaired in cancer patients. 

How Can Ozone Help With Cancer

Research has demonstrated that ozone has the ability of being an anti-metastatic agent, as well as an adjuvant for the treatment of cancer patients.

Ozone has demonstrated its effect in the regulation of the oxygen metabolism and oxygenation. For example, in the use of the aerobic pathway for the production of energy and re-establishing the normal metabolic functions. This in turn controls the use of lactic acidosis by cancer (used in anaerobic metabolism).Ozone improves tumor oxygenation by significantly and constantly increasing oxygen availability and microcirculation which may slow down tumor growth and inhibit metastasis. Although this sounds paradoxical, ozone mediated hyperoxia (refers to a state of sufficient or excess oxygen) inhibits and counteracts the HIF1A factor therefore reducing angiogenesis and improving radiotherapy and chemotherapy resistance of tumors. 

  •  Ozone increases oxygen in hypoxic cancer cells. We know that CANCER flourishes in oxygen deprived environments! This also helps in preventing metastatic growth and angiogenisis. 

  • Ozone reduces inflammation. Cancer can grow in a weakened inflamed body! 

  •  Ozone assists in detoxification, leaving the body less likely to have diseases. 

  • Ozone boosts the immune system. Cancer's enemy is the immune system! 

  • Ozone kills all types of bacteria, viruses and fungi. Cancer loves a dirty fish tank! 

  • Ozone increases cellular antioxidant levels. Inhibiting chronic oxidative stress in cancer. 

Thirdly, ozone modulates the immune system making possible the recovery of the immunological response against the tumor cells. Through the action of hydrogen peroxide, it acts as a mild inducer of cytokines in white blood cells and therefore by releasing cytokines in lymphoid microenvironments (lymph nodes, thymus, tonsils, spleen etc.) it activates the immune system usually suppressed by tumor growth.

OZONE Therapy for COLON CANCER

Ozone water, Ozone Insufflations and Major Autohmtherapy were used to reduce this colon cancer to scar tissue in 4 months. Additionally did the patient change diet, reduce food sensitivities, reduce sugar consumption,  and supplement orally and via IV infusions to reduce severe deficiencies.

OZONE Therapy Inhibits CANCER Growth

‘Ozone Selectively Inhibits Growth of Human Cancer Cells’ was a study published in 1980 concluding that ozone inhibits cancer cell growth by 90%. Human cancer cells from the lungs, breast and uterine tumors as well as non-cancerous control cells were grown in petri dishes and incubated in a controlled ozone air for a total of eight days.

The ozone had inhibited the growth of cancer cells by 40% and 60% and when the levels of ozone in the air were increased cancer cells growth was inhibited by 90%. The non-cancerous control cell was unaffected; evidently the study concluded that the mechanism for defense against ozone damage is impaired in human cancer cells.’

"Treatment with ozone/oxygen-pneumoperitoneum results in complete remission of rabbit squamous cell carcinomas"

‘Researchers found ozone therapy resulted in a complete remission in rabbits with squamous cell carcinomas. “Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts antitumorous effects in vivo. 

Therapeutic insufflation of medical ozone/oxygen (O(3)/O(2)) gas mixture into the peritoneum (O(3)/O(2)-pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O(2)) resulted in a survival rate of 3/13 animals accompanied by full tumor remission in 2 of the 3 surviving animals. 

Of the 14 sham-treated animals only 1 had spontaneous tumor remission and survived. No adverse effects or changes in standard blood parameters were observed after repeated intraperitoneal insufflations of the O(3)/O(2) or O(2) gas. Animals with O(3)/O(2)-induced tumor eradication developed tolerance against reimplantation of the VX2 tumor. 

This could be reversed by immune suppression with a combination of dexamethasone and cyclosporin A suggesting an antitumorous effect of O(3)/O(2)-mediated activation of the body's own immunosurveillance.”

“Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients"

‘Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients’ published in 2015 concluded the effectiveness of ozone. 

There study included patients previously treated in radiation for prostate cancer and persistent rectal bleeding without any response to conventional treatments.

These patients were enrolled for ozone therapy via rectal insufflations and topical ozone oil.

Following the series of ozone therapy treatments the need for blood transfusions were significantly lowered as was the need for endoscopic procedures. There were no adverse affects, except for soft and temporary flatulence post each session. Ozone therapy was concluded to be an effective treatment in radiation-induced rectal bleeding patients with prostate cancer.’

Restoration of Normoxia by Ozone Therapy May Control Neoplastic Growth: A Review and a Working Hypothesis

VELIO BOCCI, M.D., Ph.D., ALESSANDRA LARINI, Ph.D., and VANNA MICHELI, Ph.D.

In contrast to normal tissues, tumors thrive in hypoxic environments. This appears to be because they can metastasize and secrete angiopoietins for enhancing neoangiogenesis and further tumor spread. Thus, during chronic ischemia, normal tissues tend to die, while neoplasms tend to grow. 

During the past two decades, it has been shown in arteriopathic patients that ozonated autohemotherapy is therapeutically useful because it in- creases oxygen delivery in hypoxic tissues, leading to normoxia. Although several oxygenation approaches have been tested, none is able to restore normoxia permanently in patients with cancer. 

We postulate that a prolonged cycle of ozonated autohemotherapy may correct tumor hypoxia, lead to less aggressive tumor behavior, and represent a valid adjuvant during or after chemo- or radiotherapy. Moreover, it may re-equilibrate the chronic oxidative stress and reduce fatigue.

Bocci, V, Ph, D, Larini, A, Ph, D, Micheli, V & Ph, D 2005, ‘Restoration of Normoxia by Ozone Therapy May Control Neoplastic Growth : A Review and a Working Hypothesis’, vol. 11, no. 2, pp. 257–265.

 

Ozone Therapy in Cancer Treatment: State of the Art 

 

Silvia Mene´ndez, Janet Cepero, and Luis Borrego

“In a randomized controlled clinical trial by Menéndez, Cepero, & Borrego, (2008)they had 70 patients with prostatic adenocarcinoma, stage A and B. All patients treated with cobalt-60 therapy (radiation) but to 35 patients they added rectal ozone, 6 days per week at a dose of 40mg/L during the 6 weeks that lasted the radiotherapy. 

The results indicated that within the first 2 weeks of treatment with cobalt therapy the participants had an appearance of side effects. However, ozone application decreased these side effects, even to the point where they didn’t have any side effects during the first 2 weeks. 

At the end of the treatment, in 84% of the patients treated only with cobalt therapy and in 52% of the ozone group, referred to the presence of side effects, with significant differences between both groups. The prostatic specific antigen (PSA) was measured in all patients. At the beginning of the treatment no significant differences between both groups were observed. 

More Research

Rectal insufflations are a systemic administration route which has several advantages compared to major autohaemotherapy as it is easy, cost effective, there is an absence of any kind of pain and the absence of venous access that is difficult to find especially in oncological patients. 

 

Moreover, it shows the additional benefits: being absorbed through the blood vessels of the rectum it determines an oxygenation increase of the portal vein with a consequent improvement of the action of hepatic detoxification, especially in reference to the chemotherapeutics drugs. It helps to maintain a stable oxygenation level and the pH of the intestinal mucosa with subsequent reduction of the gastrointestinal side effects due to the chemotherapy agents. 

 

Considering the countless benefits of the rectal insufflations, it could be a preferable administration route in order to use ozone as an adjuvant therapy in cancer patients undergoing chemotherapy or radiation. 

Ozone Therapy in Cancer Treatment: State of the Art

Silvia Mene´ndez, Janet Cepero, and Luis Borrego

Erhlich Ascitic Tumor and Sarcoma 37 were implantedin mice and afterward the animals were treated with ozone (rectally). A significant decrease in the number of metas- tasis was obtained. In another study, ozone was applied intraperitoneally, before Lewis’ lung carcinoma inoculation. A delayed effect in the tumor development kinetics and in the increase rate of tumor volume in the ozone groups was observed. With regard to the clinical trial, patients with prostatic cancer were treated with cobalt-60 therapy and ozone (rectally), decreasing the presence of side effects (due to radiation treatment) and the prostatic specific antigen figures. However, further investigations are neces- sary to be performed, in order to be considered the ozone therapy as complementary therapy for cancer.

Cepero, J, Borrego, L & Mene, S 2008, ‘Ozone Therapy in Cancer Treatment : State of the Art’, no. December, pp. 398–404.

Restoration of Normoxia by Ozone Therapy May Control Neoplastic Growth: A Review and a Working Hypothesis

VELIO BOCCI, M.D., Ph.D., ALESSANDRA LARINI, Ph.D., and VANNA MICHELI, Ph.D.

In contrast to normal tissues, tumors thrive in hypoxic environments. This appears to be because they can metastasize and secrete angiopoietins for enhancing neoangiogenesis and further tumor spread. Thus, during chronic ischemia, normal tissues tend to die, while neoplasms tend to grow. During the past two decades, it has been shown in arteriopathic patients that ozonated autohemotherapy is therapeutically useful because it in- creases oxygen delivery in hypoxic tissues, leading to normoxia. Although several oxygenation approaches have been tested, none is able to restore normoxia permanently in patients with cancer. We postulate that a prolonged cycle of ozonated autohemotherapy may correct tumor hypoxia, lead to less aggressive tumor behavior, and represent a valid adjuvant during or after chemo- or radiotherapy. Moreover, it may re-equilibrate the chronic oxidative stress and reduce fatigue.

Bocci, V, Ph, D, Larini, A, Ph, D, Micheli, V & Ph, D 2005, ‘Restoration of Normoxia by Ozone Therapy May Control Neoplastic Growth : A Review and a Working Hypothesis’, vol. 11, no. 2, pp. 257–265.

Anti‑inflammatory effects of ozonated water in an experimental mouse model

KAZUO AZUMA, TAKURO MORI, KINYA KAWAMOTO, KOHEI KURODA, TAKESHI TSUKA,TOMOHIRO IMAGAWA, TOMOHIRO OSAKI, FUMIO ITOH, SABURO MINAMI and YOSHIHARU OKAMOTO

Previous studies have suggested that ozonated water is safe and possesses antibacterial effects for treatment of experimental peritonitis rats. In this study, we evaluated the anti‑inflammatory effects of ozonated water that was intraper- itoneally injected into an experimental inflammatory mouse model. The concentrations of dissolved ozone decreased constantly and lineally, while the half-life of dissolved ozone was 36.8±2.7 min (27˚C). The 10‑ppm ozonated water was injected intraperitoneally into mice with lipopolysaccharide (LPS)‑induced acute inflammation. The results showed that the intraperitoneal injection of ozonated water decreased the levels of tumor necrosis factor-α (TNF-α) and increased the activity of superoxide dismutase (SOD). The results suggest that ozonated water has anti‑inflammatory properties and is a potential therapeutic option for acute inflammation.

Azuma, K, Mori, T, Kawamoto, K, Kuroda, K, Tsuka, T, Imagawa, T, Osaki, T, Itoh, F, Minami, S & Okamoto, Y 2014, ‘Anti ‑ inflammatory effects of ozonated water in an experimental mouse model’, pp. 671–674.

The effects of colorectally insufflated oxygen-ozone on red blood cell rheology in rabbits

A. Seda Artis, Sami Aydogan and M. Gokhan Sahin

Department of Physiology, Faculty of Medicine, University of Erciyes, Kayseri, Turkey

Currently, with reappraisal of ozone therapy, it has been utilized worldwide in research and clinical field. Most of the studies investigating effects of ozone on blood parameters are conducted by directly ozonating the blood. Rectal insufflation is a simple, easy and inexpensive method of delivering ozone. Little is known how these gases affect some fundamental hemorheologic parameters when given by insufflation. We aimed to investigate the effects of colorectally insufflated oxygen- ozone on red blood cell rheology in rabbits. Rabbits were divided into Group 1 (control); Groups 2, 3 and 4 (oxygen rectally insufflated respectively for 15, 21 and 36 days); Groups 5, 6 and 7 (ozone rectally insufflated respectively for 15, 21 and 36 days). Erythrocyte deformability, aggregation and osmotic fragility were determined from blood samples at the end of each treatment period. Our study showed an improvement in deformability, a decrease in aggregation and an increase in fragility following a 15 day ozone treatment.With longer ozone application the changes in aggregation and fragility returned back to control levels, however its effect on deformability sustained. Therefore, more than two weeks ozone insufflation may induce adaptation to changes induced by ozone suggesting its systemic effects.

Artis, AS, Aydogan, S & Sahin, MG 2010, ‘The effects of colorectally insufflated oxygen-ozone on red blood cell rheology in rabbits’, vol. 45, pp. 329–336.

Ozone Therapy for Tumor Oxygenation: a Pilot Study

Bernardino Clavo, Juan L. Pérez, Laura López, Gerardo Suárez,  Marta Lloret, Victor Rodríguez, David Macías, Maite Santana, María A. Hernández, Roberto Martín-Oliva and Francisco Robaina

Tumor hypoxia is an adverse factor for chemotherapy and radiotherapy. Ozone therapy is a non- conventional form of medicine that has been used successfully in the treatment of ischemic disorders. This prospective study was designed to assess the effect of ozone therapy on tumor oxygenation. Eighteen subjects were recruited for the study. Systemic ozone therapy was administered by auto- hemotransfusion on three alternate days over one week. Tumor oxygenation levels were measured using polarographic needle probes before and after the first and the third ozone therapy session. Overall, no statistically significant change was observed in the tumor oxygenation in the 18 patients. However, a significant decrease was observed in hypoxic values ≤10 and ≤5 mmHg of pO2. When individually assessed, a significant and inverse non-linear correlation was observed between increase in oxygenation and the initial tumor pO2 values at each measuring time-point, thus indicating that the more poorly-oxygenated tumors benefited most (rho = –0.725; P = 0.001). Additionally, the effect of ozone therapy was found to be lower in patients with higher hemoglobin concentrations (rho = –0.531; P < 0.034). Despite being administered over a very short period, ozone therapy im- proved oxygenation in the most hypoxic tumors. Ozone therapy as adjuvant in chemo-radiotherapy warrants further research.Keywords:

Clavo, B, Pérez, JL, López, L, Suárez, G, Lloret, M, Rodríguez, V, Santana, M, Hernández, MA, Martín-oliva, R & Robaina, F 2004, ‘Ozone Therapy for Tumor Oxygenation : a Pilot Study’, vol. 1, no. 1, pp. 93–98.

Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study

Bernardino Clavo, Ana Ruiz, Marta Lloret, Laura López, Gerardo Suárez, David Macías, Victor Rodríguez, Maria A. Hernández, Roberto Martín-Oliva, Santiago Quintero, José M. Cuyás and Francisco Robaina

Advanced head and neck (H&N) tumors have a poor prognosis, and this is worsened by the occurrence of hypoxia and ischemia in the tumors. Ozonetherapy has proved useful in the treatment of ischemic syndromes, and several studies have described a potential increase of oxygenation in tissues and tumors. The aim of this prospective study was to evaluate the clinical effect of ozonetherapy in patients with advanced H&N cancer in the course of their scheduled radiotherapy. Over a period of 3 years, 19 patients with advanced H&N tumors who were undergoing treatment in our department with non- standard fractionated radiotherapy plus oral tegafur. A group of 12 patients was additionally treated with intravenous chemotherapy before and/or during radiotherapy. In the other group of seven patients, sys- temic ozonetherapy was administered twice weekly during radiotherapy. The ozonetherapy group was older (64 versus 54 years old, P?0.006), with a higher percentage of lymph node involvement (71% versus 8%, P?0.019) and with a trend to more unfavorable tumor stage (57% versus 8% IVb ?IVc stages, P?0.073). However, there was no significant difference in overall survival between the chemotherapy (median 6 months) and ozonetherapy (8 months) groups. Although these results have to be viewed with caution because of the limited number of patients, they suggest that ozonetherapy could have had some positive effect during the treatment of our patients with advanced H&N tumors. The adjuvant administration of ozonetherapy during the chemo–radiotherapy for these tumors merits further research.​

Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients

Bernardino Clavo, Norberto Santana-Rodriguez, Pedro Llontop, Dominga Gutierrez, Daniel Ceballos, Charlin Méndez, Gloria Rovira, Gerardo Suarez, Dolores Rey-Baltar, LauraGarcia-Cabrera, Gregorio Martínez-Sánchez, and Dolores Fiuza 

Introduction. Persistent radiation-induced proctitis and rectal bleeding are debilitating complications with limited therapeutic options.We present our experience with ozone therapy in the management of such refractory rectal bleeding. Methods. Patients (푛=12) previously irradiated for prostate cancer with persistent or severe rectal bleeding without response to conventional treatment were enrolled to receive ozone therapy via rectal insufflations and/or topical application of ozonized-oil. Ten (83%) patients had Grade 3 or Grade 4 toxicity.Median follow-up aſter ozone therapy was 104months (range: 52–119). Results.Following ozone therapy, the median grade of toxicity improved from 3 to 1 (푝 < 0.001) and the number of endoscopy treatments from 37 to 4 (푝 = 0.032). Hemoglobin levels changed from 11.1 (7–14) g/dL to 13 (10–15) g/dL, before and aſter ozone therapy, respectively (푝 = 0.008). Ozone therapy was well tolerated and no adverse effects were noted, except soſt and temporary flatulence for some hours aſter each session. Conclusions. Ozone therapy was effective in radiation-induced rectal bleeding in prostate cancer patients without serious adverse events. It proved useful in themanagement of rectal bleeding and merits further evaluation.1.

Background. Some patients with medically unexplained symptoms or alternative medical diagnoses suspect thatthey chronically suffer from the tick-borne infection Lyme disease. These patients are commonly targeted by pro- viders of alternative therapies. This study was designed to identify and characterize the range of unorthodox alter- native therapies advertised to patients with a diagnosis of Lyme disease.

Methods. Internet searches using the Google search enginewere performed to identify thewebsites of clinics andservices that marketed nonantimicrobial therapies for Lyme disease. We subsequently used the PubMed search engine to identify any scientific studies evaluating such treatments for Lyme disease. Websites were included in our review so long as they advertised a commercial, nonantimicrobial product or service that specifically mentioned utility for Lyme disease. Websites with patient testimonials (such as discussion groups) were excluded unless the testimonial appeared as marketing on a commercial site.

Results. More than 30 alternative treatments were identified, which fell into several broad categories: these included oxygen and reactive oxygen therapy; energy and radiation-based therapies; nutritional therapy; chelation and heavy metal therapy; and biological and pharmacological therapies ranging from certain medications without recognized therapeutic effects on Borrelia burgdorgeri to stem cell transplantation. Review of the medical literature did not substantiate efficacy or, in most cases, any rationale for the advertised treatments.

Conclusions. Providers of alternative therapies commonly target patients who believe they have Lyme disease.The efficacy of these unconventional treatments for Lyme disease is not supported by scientific evidence, and in many cases they are potentially harmful.

Ozone therapy: A clinical review

A. M. Elvis and J. S. Ekta 

Ozone (O ) gas discovered in the mid-nineteenth century is a molecule consisting of three atoms of3oxygen in a dynamically unstable structure due to the presence of mesomeric states. Although O has3dangerous effects, yet researchers believe it has many therapeutic effects. Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and with minimal and preventable side effects. Medical O is used to disinfect and treat disease. Mechanism of actions is by3inactivation of bacteria, viruses, fungi, yeast and protozoa, stimulation of oxygen metabolism, activation of the immune system. Medication forms in a gaseous state are somewhat unusual, and it is for this reason that special application techniques have had to be developed for the safe use of O . In local applications as3in the treatment of external wounds, its application in the form of a transcutaneous O gas bath has3established itself as being the most practical and useful method, for example at low (sub-atmospheric) pressure in a closed system guaranteeing no escape of O into the surrounding air. Ozonized water, whose3use is particularly known in dental medicine, is optimally applied as a spray or compress. Diseases treated are infected wounds, circulatory disorders, geriatric conditions, macular degeneration, viral diseases, rheumatism/arthritis, cancer, SARS and AIDS.

Elvis, AM & Ekta, JS 2011, ‘Ozone therapy : A clinical review’, vol. 2, no. 1, pp. 66–70.

Ozone Selectively Inhibits Growth ofHuman Cancer Cells

WILLIAM A. HASELTINE KWOK MING LoALAN D. D'ANDREA

The growth ofhuman cancer cellsfrom lung, breast, and uterine tumorswas selectively inhibited in a dose-dependent manner by ozone at 0.3 to 0.8 part per million of ozone in ambient air during 8 days of culture. Human lung diploidfibro- blasts served as noncancerous control cells. The presence ofozone at 0.3 to 0.5 part per million inhibited cancer cell growth 40 and 60 percent,. respectively. The non- cancerous lung cells were unaffected at these levels. Exposure to ozone at 0.8 part per million inhibited cancer cell growth more than 90 percent and control cell growth less than 50 percent. Evidently, the mechanisms for defense against ozone damage are impaired in human cancer cells. 

Meehan, T, Straub, K, Calvin, M & Lon-, N 1979, ‘Ozone Selectively Inhibits Growth of Human Cancer Cells’, vol. 79, no. 1975, pp. 2–4.

Effect of ozone/oxygen mixture on systemic oxidative stress and organic damage

Dailen Guanche, Zullyt Zamora , Frank Hernández, Karel Mena, Yaima Alonso, Maydelis Roda, Maritza Gonzáles, and Ricardo Gonzales

Ozone is a molecule of high energetic content. Its great oxidative power has been used in medicine for the treat- ment of several illnesses with a wide spectrum. The rectal insufflation with a mixture of ozone/oxygen is considered as a simple therapy, not painful, of low cost and practically free from adverse effects. Given its potential oxidation and lack of side-effects, the objective has been to know the state of different indexes of redox state in blood which may contribute to understanding the mechanism by which mixtures of ozone/oxygen administered by intrarectal route are able to exert actions on other organs. With this purpose female rabbits were used, distributed into four groups, and three doses of ozone/oxygen mixture were tested. When treatment was finished, the determination of pro-oxidant and antioxidant markers was carried out. Also indexes of organic damage were determined. Ozone doses administered to rabbits did not cause adverse effects and mortality did not show significant changes rela- tive to tissue damages and they increased enzymes activities belonging to the first line antioxidant defences. The results demonstrate that ozone/oxygen mixture administered by rectal insufflations is innocuous and it is able to increase the antioxidant defense of the organism.

Guanche, D, Zamora, Z, Hernández, F, Mena, K, Alonso, Y, Roda, M, Gonzáles, M & Gonzales, R 2010, ‘Effect of ozone / oxygen mixture on systemic oxidative stress and organic damage’, vol. 20, no. November 2009, pp. 25–30.

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